First, we lyse the sample with the specially formulated lysis buffer, after which the nucleic acids bind to the added magnetics beads. During this step, DNases and RNases are deactivated. The magnetic plate separates the magnetic beads with RNA from the lysates. After a few rapid wash steps to remove trace contaminants (e.g. proteins and cellular debris), we elute the RNA in nuclease free water.
SARS-CoV-2 research is an important application of the Clean Viral RNA Swab Kit, but certainly not the only one. The system and kit can be used for many respiratory tract infections with swabs in either Universal or Virus Transport Medium, extracting the RNA for PCR or NGS experiments. Not only with existing viruses, but also variant that will appear in the future.